Open AccessTransfusion-acquired Hemoglobinopathies: A Report of Two Cases
Author(s) -
Venkatesan Somasundaram,
Abhishek Purohit,
Prabhu Manivannan,
Renu Saxena
Publication year - 2015
Publication title -
journal of laboratory physicians
Language(s) - English
Resource type - Journals
eISSN - 0974-7826
pISSN - 0974-2727
DOI - 10.4103/0974-2727.163128
Subject(s) - hemoglobinopathy , abnormality , medicine , blood transfusion , hemoglobin , high performance liquid chromatography , spurious relationship , pediatrics , hemolytic anemia , chromatography , chemistry , machine learning , computer science , psychiatry
Transfusion-acquired hemoglobinopathy occurs when a carrier of hemoglobinopathy with no significant abnormalities donates blood, and the blood is transfused to a recipient. This process can lead to spurious results in the recipient without any clinical abnormality or infrequently can result in disastrous situations. The incidental finding of such posttransfusion related abnormal peaks in hemoglobin high-performance liquid chromatography (Hb HPLC) may cause diagnostic dilemmas and result in unnecessary laboratory testing. Here, we report two such cases of transfusion-acquired hemoglobinopathies, which were subsequently resolved by the abnormally low percentage of the Hb variants, transient nature of the peaks, and parental Hb HPLC.