Open AccessContinuous intravenous flumazenil infusion in a patient with chlordiazepoxide toxicity and hepatic encephalopathy
Author(s) -
Moh’d Al-Halawani,
Parijat Sen,
Yazan Abdeen,
Hamid Shaaban,
Alan Klukowicz,
Richard A. Miller
Publication year - 2015
Publication title -
journal of emergencies, trauma and shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.313
H-Index - 29
eISSN - 0974-519X
pISSN - 0974-2700
DOI - 10.4103/0974-2700.145422
Subject(s) - flumazenil , benzodiazepine , chlordiazepoxide , medicine , hepatic encephalopathy , anesthesia , hemoperfusion , encephalopathy , diazepam , cirrhosis , receptor , hemodialysis
Flumazenil, a benzodiazepine receptor antagonist, is the drug of choice for the diagnosis and treatment of benzodiazepine overdose. We are presenting a patient with chronic alcoholism and alcoholic liver disease, who came with alcohol withdrawal symptoms and treated chlordiazepoxide. Subsequently he developed a prolonged change in mental status that required treatment for benzodiazepine overdose and hepatic encephalopathy with flumazenil infusion for 28 days.