Open AccessEffects of aminoguanidine, a potent nitric oxide synthase inhibitor, on myocardial and organ structure in a rat model of hemorrhagic shock
Author(s) -
Mona Soliman
Publication year - 2014
Publication title -
journal of emergencies, trauma and shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.313
H-Index - 29
eISSN - 0974-519X
pISSN - 0974-2700
DOI - 10.4103/0974-2700.136864
Subject(s) - peroxynitrite , nitric oxide synthase , nitric oxide , hemorrhagic shock , shock (circulatory) , in vivo , blood pressure , chemistry , medicine , resuscitation , pharmacology , endocrinology , pathology , anesthesia , enzyme , biology , biochemistry , superoxide , microbiology and biotechnology
Nitric oxide (NO) has been shown to increase following hemorrhagic shock (HS). Peroxynitrite is produced by the reaction of NO with reactive oxygen species, leads to nitrosative stress mediated organ injury. We examined the protective effects of a potent inhibitor of NO synthase, aminoguanidine (AG), on myocardial and multiple organ structure in a rat model of HS.