Open AccessBlood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma
Author(s) -
Pär I. Johansson,
Nis A. Windeløv,
Lars S. Rasmussen,
Anne Marie Sørensen,
Sisse Rye Ostrowski
Publication year - 2013
Publication title -
journal of emergencies, trauma and shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.313
H-Index - 29
eISSN - 0974-519X
pISSN - 0974-2700
DOI - 10.4103/0974-2700.115327
Subject(s) - hyperfibrinolysis , inflammation , thrombomodulin , coagulopathy , medicine , hemostasis , fibrinolysis , endothelial activation , plasminogen activator , endothelial dysfunction , tissue plasminogen activator , endocrinology , immunology , thrombin , platelet
Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to the injury that involves the neurohumoral, inflammatory and hemostatic systems.