Open AccessRole of adipose-derived stem cells in fat grafting and reconstructive surgery
Author(s) -
Shaun Tan,
Zhi Yang Ng,
Weiqing Zhan,
Warren M. Rozen
Publication year - 2016
Publication title -
journal of cutaneous and aesthetic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.44
H-Index - 13
eISSN - 0974-5157
pISSN - 0974-2077
DOI - 10.4103/0974-2077.191672
Subject(s) - medicine , stromal vascular fraction , liposuction , adipose tissue , surgery , stem cell , reconstructive surgery , grafting , transplantation , stromal cell , pathology , chemistry , organic chemistry , biology , genetics , polymer
Autologous fat grafting is commonly utilised to reconstruct soft tissue defects caused by ageing, trauma, chronic wounds and cancer resection. The benefits of fat grafting are minimal donor site morbidity and ease of availability through liposuction or lipectomy. Nonetheless, survival and longevity of fat grafts remain poor post-engraftment. Various methods to enhance fat graft survival are currently under investigation and its stem cell constituents are of particular interest. Cell-assisted lipotransfer refers to the addition of adipose-derived stem cell (ASC) rich component of stromal vascular fraction to lipoaspirate, the results of which have proven promising. This article aims to review the role of ASCs in fat grafting and reconstructive surgery.