Open AccessRole of 14-bp deletion/insertion polymorphism in exon 8 of the HLA-G gene in recurrent spontaneous abortion patients
Author(s) -
U. Shankarkumar,
Aruna Shankarkumar,
Z Chedda,
Kanjaksha Ghosh
Publication year - 2011
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/0974-1208.92289
Subject(s) - hla g , exon , haplotype , allele , biology , human leukocyte antigen , genetics , microbiology and biotechnology , indel mutation , insertion , gene , hla b , genotype , antigen , mutation , single nucleotide polymorphism
Human leukocyte antigen (HLA)-G belongs to the nonclassical Class I major histocompatibility complex, and is predominantly and specifically found on the extravillous cytotrophoblast cells of the placenta. HLA-G has been postulated as an important immunotolerant molecule in maintaining successful pregnancy and maternal tolerance of the semiallogenic fetus. Recent reports indicate that the 14-bp deletion/insertion polymorphism in exon 8 of the 3'UTR region of the HLA-G gene influences the HLA-G mRNA stability and isoform splicing patterns, thus modulating the levels of HLA-G expression.