Open AccessRole of anti-human lymphocyte culture cytotoxic antibodies in recurrent spontaneous pregnancy loss women
Author(s) -
U. Shankarkumar,
Aruna Shankarkumar,
Vanita Ramrakhiyani,
Kanjaksha Ghosh
Publication year - 2011
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/0974-1208.82354
Subject(s) - antibody , human leukocyte antigen , pregnancy , medicine , immunology , titer , antigen , gestation , cytotoxic t cell , blocking antibody , isoantibodies , antibody titer , biology , in vitro , genetics
Recurrent spontaneous pregnancy (RSA) is defined as a sequence of three or more consecutive spontaneous abortions. One of the major causes of RSA is immunological where alloimmune antibodies develop towards human leucocyte antigen (HLA) antigens. Earlier research had suggested that anti-HLA antibodies are produced in normal women; studies have been reported that normal pregnant women develop anti-HLA antibodies, mostly after 20-28 weeks of gestation.