Open AccessScreening of ′Y′ chromosome microdeletions in Iranian infertile males
Author(s) -
Ali Mohammad Malekasgar,
Hayat Mombaini
Publication year - 2008
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/0974-1208.38973
Subject(s) - azoospermia , y chromosome microdeletion , azoospermia factor , y chromosome , oligospermia , male infertility , locus (genetics) , genetics , biology , infertility , population , andrology , gynecology , klinefelter syndrome , sequence tagged site , chromosome , medicine , gene , gene mapping , pregnancy , endocrinology , environmental health
It has been hypothesized that microdeletions of Yq may account for a significant proportion of men with infertility. Three nonoverlapping regions, referred to as "azoospermia factors" (AZFa, b, c from proximal to distal Yq) have been defined as spermatogenesis loci and deletions in these regions have been shown to be pathogenically involved in male infertility associated with azoospermia or severe oligospermia.