Open AccessPre-implantation genetic screening using fluorescence in situ hybridization in couples of Indian ethnicity: Is there a scope?
Author(s) -
Shailaja Gada Saxena,
Kundanbala Desai,
Lata Shewale,
Prabhat Ranjan
Publication year - 2014
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/0974-1208.130812
Subject(s) - fluorescence in situ hybridization , infertility , unexplained infertility , implantation failure , obstetrics , in vitro fertilisation , gynecology , pregnancy , medicine , advanced maternal age , assisted reproductive technology , spontaneous conception , twin pregnancy , live birth , blastomere , embryo , biology , fetus , genetics , embryogenesis , chromosome , gene
There is a high incidence of numerical chromosomal aberration in couples with repeated in vitro fertilization (IVF) failure, advanced maternal age, repeated unexplained abortions, severe male factor infertility and unexplained infertility. Pre-implantation genetic screening (PGS), a variant of pre-implantation genetic diagnosis, screens numerical chromosomal aberrations in couples with normal karyotype, experiencing poor reproductive outcome. The present study includes the results of the initial pilot study on 9 couples who underwent 10 PGS cycles.