Open AccessComparison of two algorithms to confirm and discriminate samples initially reactive for nucleic acid amplification tests
Author(s) -
Aseem Kumar Tiwari,
Ravi C Dara,
Dinesh Arora,
Geet Aggarwal,
Ganesh Rawat,
Vimarsh Raina
Publication year - 2017
Publication title -
asian journal of transfusion science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 22
eISSN - 1998-3565
pISSN - 0973-6247
DOI - 10.4103/0973-6247.214330
Subject(s) - nat , algorithm , replicate , nucleic acid test , medicine , nucleic acid , nucleic acid amplification tests , serology , computer science , virology , statistics , immunology , biology , antibody , mathematics , genetics , covid-19 , disease , chlamydia trachomatis , infectious disease (medical specialty)
Blood centers in India have published individual donor nucleic acid testing (ID-NAT) data based on an algorithm (Algorithm A) where serologically negative, NAT reactive sample was subsequently tested with discriminatory NAT (d-NAT), and on the basis of d-NAT, initial reactive samples were classified as "NAT yield" or inconclusive. We followed Algorithm B based on replicate testing and Ultrio Plus assay and compared the results with Algorithm A with Ultrio assay.