Open AccessAnti-N antibody reacting at 37°C: An unusual occurrence interfering with routine testing: Two interesting cases
Author(s) -
Vijay Kumawat,
Ashish Jain,
Neelam Marwaha,
Ratti Ram Sharma
Publication year - 2015
Publication title -
asian journal of transfusion science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 22
eISSN - 1998-3565
pISSN - 0973-6247
DOI - 10.4103/0973-6247.150964
Subject(s) - medicine , antibody , abo blood group system , hemolytic disease of the newborn (abo) , fetus , immune system , immunology , isoantibodies , pregnancy , biology , genetics
Most anti-N antibodies are naturally occurring, IgM antibodies, and not active above 25°C and are not clinically significant but IgG anti- N has also been described. Immune anti-N resulting from multiple transfusions does occur & has been implicated as the cause of hemolytic transfusion reactions and mild hemolytic disease of fetus and newborn. Anti- N reacting at room temperature can be a cause for ABO blood group discrepancy.