Open AccessResponse of cardiac endothelial nitric oxide synthase to plasma viscosity modulation in acute isovolemic hemodilution
Author(s) -
Kanyanatt Kanokwiroon,
Surapong Chatpun
Publication year - 2014
Publication title -
asian journal of transfusion science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 22
eISSN - 1998-3565
pISSN - 0973-6247
DOI - 10.4103/0973-6247.137444
Subject(s) - enos , medicine , hematocrit , blood viscosity , nitric oxide , mean arterial pressure , cardiac output , microcirculation , shock (circulatory) , nitric oxide synthase , hemorheology , endocrinology , anesthesia , hemodynamics , blood pressure , heart rate
Endothelial nitric oxide synthase (eNOS) is generally expressed in endocardial cells, vascular endothelial cells and ventricular myocytes. However, there is no experimental study elucidating the relationship between cardiac eNOS expression and elevated plasma viscosity in low oxygen delivery pathological conditions such as hemorrhagic shock-resuscitation and hemodilution. This study tested the hypothesis that elevated plasma viscosity increases cardiac eNOS expression in a hemodilution model, leading to positive effects on cardiac performance.