Open AccessFollicular dendritic cell sarcoma: A diagnostic challenge !
Author(s) -
Ajay Malik,
Ajit Veniyoor,
B Fanthome,
Vibha Dutta
Publication year - 2012
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.98998
Subject(s) - follicular dendritic cells , pathology , vimentin , cd23 , sarcoma , immunohistochemistry , mediastinum , biology , medicine , anatomy , t cell , antigen presenting cell , immunology , immune system , antibody , immunoglobulin e
Follicular dendritic cell sarcoma (FDCS) is a spindle cell neoplasm of histiocytic-dendritic cells origin. It is known to occur in lymph nodes and rarely has been reported in extranodal tissues like head and neck, mediastinum and gastrointestinal tract. We herein report the first FDCS arising from anal canal in a 56-year-old man. The tumor was composed of bland short spindle cells in focal whorl formation with interspersed few lymphocytes. The tumor cells were classically positive for CD21, CD23, CD35 and vimentin. Despite its misleading morphology, immunohistochemistry helped us to reach a conclusive diagnosis for relevant therapy.