Open AccessCytology of hyalinising trabecular adenoma-like variant of medullary thyroid carcinoma
Author(s) -
KV Santosh,
Sujata Raychaudhuri,
H Subramanya,
BJ Naveen Kumar
Publication year - 2011
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.82916
Subject(s) - thyroid , pathology , medullary cavity , histopathology , thyroid neoplasm , nodule (geology) , medicine , thyroid carcinoma , thyroidectomy , carcinoma , cytology , medullary carcinoma , adenoma , neoplasm , population , anatomy , biology , paleontology , environmental health
Medullary thyroid carcinoma is a rare thyroid neoplasm that can be either sporadic or familial. It occurs in adults, presenting as a solitary cold nodule on thyroid scan. Most are solid, firm, and non-encapsulated, and occur in the mid portion or upper half of the thyroid gland, corresponding to areas with greater numbers of C cells. We present a case of a 36-year-old female with a swelling in the front of her neck for six years. Fine needle aspiration done elsewhere revealed spindle cells, suggestive of a 'spindle cell neoplasm'. The histopathology of the thyroidectomy specimen showed features of a hyalinizing trabecular adenoma-like variant of medullary carcinoma. Subsequently, we performed aspiration on the received specimen and studied the cytological findings. The cytological diagnosis of this variant requires identification of the dual spindle and ovoid cell population and the granular neuroendocrine chromatin.