Open AccessSerum phosphodiesterase levels in oral cancer
Author(s) -
Krishnananda Prabhu,
Dilip G Naik,
Sujoy Ray,
B M Vadiraja,
Asha Kamath
Publication year - 2011
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.82911
Subject(s) - medicine , cancer , angiogenesis , phosphodiesterase , biopsy , oncology , pathology , biology , enzyme , biochemistry
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies recognized nowadays. Its early detection is the better alternative to provide a good quality of life for the patients. During the last years, several studies have identified potential biomarkers of OSCC progression and prognosis. The phosphodiesterases (PDEs) are responsible for the hydrolysis of the second messengers with a fundamental role in the transduction of the intracellular signals. Variations in PDE activity have been correlated to different pathological mechanisms, such as cellular differentiation, apoptosis, and tumor invasivity. PDEs are also known to play a role in tumor growth by influencing angiogenesis.