Intensity-modulated radiation to spare neural stem cells in brain tumors: A computational platform for evaluation of physical and biological dose metrics | Zendy

Arun Jaganathan | Zendy; Meena Tiwari | Zendy; Rahul Phansekar | Zendy; Rajkumar Panta | Zendy; Nagraj Huilgol | Zendy

Open Access

Intensity-modulated radiation to spare neural stem cells in brain tumors: A computational platform for evaluation of physical and biological dose metrics

Author(s) -

Arun Jaganathan,

Meena Tiwari,

Rahul Phansekar,

Rajkumar Panta,

Nagraj Huilgol

Publication year - 2011

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.80463

Subject(s) - medicine , radiation therapy , magnetic resonance imaging , nuclear medicine , radiology

Neurocognitive effects following whole-brain and partial-brain irradiation can cause considerable morbidity. Sparing of neural stem cells (NSCs) is proposed as an avenue for reducing the long-term radiation-induced defects in learning, memory, and intelligence. We performed an analytical study to spare the NSC from partial-brain irradiation by intensity-modulated radiotherapy (IMRT).

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