Open AccessApoptosis induced by Magnolia Grandiflora extract in chlorambucil-resistant B-chronic lymphocytic leukemia cells
Author(s) -
Gustavo Horacio Marín,
Eduardo Mansilla
Publication year - 2010
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.77107
Subject(s) - chlorambucil , chronic lymphocytic leukemia , apoptosis , annexin , magnolia officinalis , traditional medicine , herb , biology , leukemia , programmed cell death , chemistry , biochemistry , medicine , traditional chinese medicine , immunology , medicinal herbs , chemotherapy , pathology , cyclophosphamide , alternative medicine , genetics
B-cell chronic lymphocytic leukemia (B-CLL) still remains as an uncurable disease. Even the newest antineoplastic agents have demonstrated limitations in their efficacy. For this reason, further research of new compounds must be done. New pharmacological properties can be obtained from a great diversity botanical species. Among these products, Magnolia Grandiflora receives our attention since it mainly contains Honokiol which had demonstrated effect against B-CLL cells activating different cell death pathways.