Open AccessDistinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway
Author(s) -
Amit A. Gokhale,
Ratika Kunder,
Atul Goel,
Rajiv Sarin,
Aliasgar Moiyadi,
Ashok K Shenoy,
Chandrasekhar Mamidipally,
Santosh Noronha,
Sadhana Kannan,
Neelam Shirsat
Publication year - 2010
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.77072
Subject(s) - wnt signaling pathway , microrna , signature (topology) , cancer research , computational biology , biology , signal transduction , microbiology and biotechnology , genetics , gene , geometry , mathematics
Medulloblastoma is a malignant brain tumor that occurs predominantly in children. Current risk stratification based on clinical parameters is inadequate for accurate prognostication. MicroRNA expression is known to be deregulated in various cancers and has been found to be useful in predicting tumor behavior. In order to get a better understanding of medulloblastoma biology, miRNA profiling of medulloblastomas was carried out in parallel with expression profiling of protein-coding genes.