Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway | Zendy

Neelam Shirsat | Zendy; Amit Gokhale | Zendy; Ratika Kunder | Zendy; Atul Goel | Zendy; Rajiv Sarin | Zendy; Aliasgar Moiyadi | Zendy; Asha Shenoy | Zendy; Chandrasekhar Mamidipally | Zendy; Santosh Noronha | Zendy; Sadhana Kannan | Zendy

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Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway

Author(s) -

Neelam Shirsat,

Amit Gokhale,

Ratika Kunder,

Atul Goel,

Rajiv Sarin,

Aliasgar Moiyadi,

Asha Shenoy,

Chandrasekhar Mamidipally,

Santosh Noronha,

Sadhana Kannan

Publication year - 2010

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.77072

Subject(s) - wnt signaling pathway , microrna , signature (topology) , cancer research , computational biology , biology , signal transduction , microbiology and biotechnology , genetics , gene , geometry , mathematics

Medulloblastoma is a malignant brain tumor that occurs predominantly in children. Current risk stratification based on clinical parameters is inadequate for accurate prognostication. MicroRNA expression is known to be deregulated in various cancers and has been found to be useful in predicting tumor behavior. In order to get a better understanding of medulloblastoma biology, miRNA profiling of medulloblastomas was carried out in parallel with expression profiling of protein-coding genes.

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