Open AccessAssociation between polymorphisms of interleukin-17A G197A and interleukin-17F A7488G and risk of colorectal cancer
Author(s) -
Golnaz Samiei,
Wai Kien Yip,
Pooi Pooi Leong,
Mohd Faisal Jabar,
Noraini Mohd Dusa,
Norhafizah Mohtarrudin,
Heng Fong Seow
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.235345
Subject(s) - genotype , odds ratio , genotyping , colorectal cancer , medicine , interleukin , confidence interval , interleukin 17 , oncology , immunology , gastroenterology , cancer , cytokine , biology , genetics , gene
Interleukin (IL)-17A and IL-17F are inflammatory cytokines mainly produced by T helper 17 cells. IL-17A is known to be protumorigenic while IL-17F has a protective role in cancer. A number of studies have been conducted to determine the association between polymorphisms of IL-17AG197A (rs2275913) and IL-17FA7488G (rs763780) and risk of cancers. No studies have yet to be conducted to genotype the IL-17AG197A polymorphism in colorectal cancer (CRC).