Open AccessImmunohistochemical expression of TWIST in oral squamous cell carcinoma and its correlation with clinicopathologic factors
Author(s) -
Maryam Seyedmajidi,
Safoura Seifi,
Dariush Moslemi,
Seyyedeh-Fatemeh Mozaffari,
Hemmat Gholinia,
Zahra Zolfaghari
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.224350
Subject(s) - immunohistochemistry , pathology , twist , carcinogenesis , epithelial–mesenchymal transition , medicine , metastasis , cancer , cell , cancer research , biology , geometry , mathematics , genetics
TWIST is a transcription factor that plays a key role in the development of primary tumor to metastatic stage of cancer. It is an inhibitor of E-cadherin in epithelial-to-mesenchymal transformation process (epithelial-mesenchymal transition). Few studies are available on the use of TWIST as a goal in molecular-targeted therapy. The aim of this study was to evaluate of TWIST expression in oral squamous cell carcinoma (OSCC) and its correlation with clinicopathologic factors.