Open AccessThe administration of peroxisome proliferator-activated receptors α/γ agonist TZD18 inhibits cell growth and induces apoptosis in human gastric cancer cell lines
Author(s) -
Yuhong Ma,
Bin Wang,
Ling Li,
Fang Wang,
Xuan Xia
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.208753
Subject(s) - apoptosis , cytochrome c , cell growth , microbiology and biotechnology , biology , cell culture , flow cytometry , receptor , cancer cell , peroxisome proliferator activated receptor , biochemistry , cancer , genetics
This study is to investigate the effects of a novel peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist TZD18 on cell growth, apoptosis, caspase activity, mitochondrial membrane potential, cytochrome c release, and apoptotic-related protein expression in MKN-45 cells.