Open AccessGambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway
Author(s) -
Lijun Ye,
Jimei Zhou,
Wei Zhao,
Pengfei Jiao,
Gaofei Ren,
Shujun Wang
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.206866
Subject(s) - autophagy , gambogic acid , reactive oxygen species , chemistry , apoptosis , microbiology and biotechnology , cell growth , cancer research , flow cytometry , cell , programmed cell death , pharmacology , medicine , biology , biochemistry , immunology
Garcinia hanburyi is a traditional herbal medicine with activities of anti-inflammation and hemostasis used by people in South Asia. Gambogic acid (GA) is the main active component extracted from it, which has anticancer and anti-inflammatory effects. The aim of the current study is to investigate the molecular mechanisms of GA's effective anticancer activity.