Gambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway | Zendy

Lijun Ye | Zendy; Jimei Zhou | Zendy; Wei Zhao | Zendy; Pengfei Jiao | Zendy; Gaofei Ren | Zendy; Shujun Wang | Zendy

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Gambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway

Author(s) -

Lijun Ye,

Jimei Zhou,

Wei Zhao,

Pengfei Jiao,

Gaofei Ren,

Shujun Wang

Publication year - 2017

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.206866

Subject(s) - autophagy , gambogic acid , reactive oxygen species , chemistry , apoptosis , microbiology and biotechnology , cell growth , cancer research , flow cytometry , cell , programmed cell death , pharmacology , medicine , biology , biochemistry , immunology

Garcinia hanburyi is a traditional herbal medicine with activities of anti-inflammation and hemostasis used by people in South Asia. Gambogic acid (GA) is the main active component extracted from it, which has anticancer and anti-inflammatory effects. The aim of the current study is to investigate the molecular mechanisms of GA's effective anticancer activity.

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