Open AccessSolanum nigrum polysaccharide inhibits tumor growth in H22-bearing mice through regulation of caspase-3 and bcl-2
Author(s) -
Yueyan Huang,
Miao Yin,
Linlin Pan,
Qian Yu,
Qifeng Zhu,
Weizhen Xu,
Baoyue Ding,
Yanping Ji,
Jian Zhou
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.206862
Subject(s) - apoptosis , immunohistochemistry , spleen , caspase 3 , snp , downregulation and upregulation , immune system , biology , pharmacology , chemistry , immunology , single nucleotide polymorphism , biochemistry , genotype , programmed cell death , gene
The objective of this study was to investigate the effect of Solanum nigrum polysaccharides (SNPs) on tumor growth in H22 hepatocarcinoma cells bearing mice and explore the mechanism by focusing on the regulation of the expression of caspase-3 and bcl-2.