Open AccessIn vitro activity of probiotic Lactobacillus reuteri against gastric cancer progression by downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor gene expression
Author(s) -
Bahareh Rasouli,
Ali Ghadimi-Darsajini,
Reza Negarandeh,
Gholam-Reza Iragian
Publication year - 2017
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.204897
Subject(s) - urokinase receptor , lactobacillus reuteri , downregulation and upregulation , cancer research , cancer cell , plasminogen activator , biology , cancer , cell culture , microbiology and biotechnology , chemistry , probiotic , endocrinology , gene , biochemistry , genetics , bacteria
Gastric cancer (GC) is the third leading cause of cancer death, and most patients represent metastatic phenotype at the time of diagnosis. Urokinase plasminogen activator (uPA) system is well known for its critical roles in cancer cells invasion since uPA/uPA receptor (uPAR) overexpresses in several cancers. Subsequently, suppression of uPA/uPAR gene expression improves patients overall survival and prevents cancer progression.