Open AccessNuclear forkhead box O3a accumulation contributing to the proliferative suppression in liver cancer cells by PI3K/Akt signaling pathway
Author(s) -
Yu Hou,
Ge Sun,
Jiang Xu,
Zhenfang Zhu,
Jijin Yang
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.204891
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , cancer research , mtt assay , cell growth , chemistry , liver cancer , viability assay , oncogene , cell , signal transduction , microbiology and biotechnology , biology , cell cycle , biochemistry , hepatocellular carcinoma
Serine/threonine kinase is originally identified as an oncogene and the forkhead box transcription factor forkhead box O3a (Foxo3a) has been found to be decreased in various human cancers. In the present study, we explored the expression of Akt and FOXO3a in liver cancer cells.