Open AccessGanodermanontriol inhibits expression of special AT rich sequence binding protein 1 gene in human hepatocellular carcinoma
Author(s) -
Chengkai Xu,
Hanbin Guo,
Danli Kong,
Dong Pang,
Yuanlin Ding
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.203597
Subject(s) - hepatocellular carcinoma , metastasis , apoptosis , cancer research , cell growth , liver cancer , western blot , flow cytometry , biology , mtt assay , cancer , microbiology and biotechnology , medicine , gene , genetics
The metastasis of liver cancer is a major cause of clinical treatment failure, restrain, and control the cancer metastasis is the major strategy of the treatment and prevention of the disease. Special AT-rich sequence-binding protein 1 (SATB1) gene was overexpressed in many malignant tumors and considered as a potential target of anticancer drug. This study investigated the mechanism how ganodermanontriol effect the expression of SATB1 and thus inhibits the growth and metastasis in hepatocellular carcinoma (HCC).