Open AccessEvaluation of the effect of hesperidin on vascular endothelial growth factor gene expression in rat skin animal models following cobalt-60 gamma irradiation
Author(s) -
Gholamhassan Haddadi,
Akbar Abbaszadeh,
Mohammad Amin Mosleh-Shirazi,
Mohammad Ali Okhovat,
Ashkan Salajeghe,
Zhila Ghorbani
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.202892
Subject(s) - hesperidin , vascular endothelial growth factor , housekeeping gene , gene expression , pharmacology , gene , ionizing radiation , medicine , endocrinology , biology , andrology , irradiation , biochemistry , vegf receptors , pathology , physics , alternative medicine , nuclear physics
Skin is highly prone to radiation damage. Radiation burn is defined as damage to the skin or other biological tissues induced by radiofrequency or ionizing radiation. Vascular endothelial growth factor (VEGF) is a heparin-binded pro-angiogenic factor. Flavonoids belong to a family of polyphenol chemical compounds that are frequently present in fruits and vegetables. Hesperidin is an agent belonging to the flavonoid family. The aim of this study is to investigate whether hesperidin can affect the VEGF gene expression in rat skin following gamma irradiation or not.