Open AccessTo evaluate immunoreactivity of cyclooxygenase-2 in cases of endometrial carcinoma and correlate it with expression of p53 and vascular endothelial growth factor
Author(s) -
Sunita Bs,
Arunava Sen,
Virender Suhag
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.202890
Subject(s) - endometrial cancer , medicine , vascular endothelial growth factor , stage (stratigraphy) , carcinoma , carcinogenesis , cyclooxygenase , immunohistochemistry , proportional hazards model , endometrium , angiogenesis , oncology , cancer , pathology , vegf receptors , biology , enzyme , paleontology , biochemistry
Increased levels of prostaglandins have been detected in cancers of several anatomic sites, including those of endometrium. Several studies have shown that cyclooxygenase-2 (COX-2) expression is aberrantly increased in various human epithelial cancers, and cellular up-regulation of COX-2 may be a common mechanism in epithelial carcinogenesis.