Open AccessEvaluation of hypoxia inducible factor-1 alpha gene expression in colorectal cancer stages of Iranian patients
Author(s) -
Reyhaneh Nassiri Mansour,
Seyed Ehsan Enderami,
Abdolreza Ardeshirylajimi,
Koorosh Fooladsaz,
Mojtaba Fathi,
Shahla Moahammad Ganji
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.199542
Subject(s) - colorectal cancer , immunohistochemistry , carcinogenesis , hypoxia (environmental) , gene expression , alpha (finance) , gene , cancer , hypoxia inducible factors , metastasis , stage (stratigraphy) , cancer research , medicine , biology , oncology , pathology , chemistry , genetics , surgery , construct validity , organic chemistry , oxygen , patient satisfaction , paleontology
Colorectal cancer (CRC) is the fourth most prevalent cancer globally. Several factors have roles in cancer establishment. One of the most important factors is hypoxia that induces hypoxia inducible factor-1 (HIF-1). The HIF-1 alpha overexpressed in hypoxia conditions and plays a pivotal role in carcinogenesis features. In this study, we aimed to examine the efficiency of HIF-1 alpha gene expression at mRNA and protein's level for CRC diagnosing and staging.