Open AccessA3 adenosine receptor agonist induce G1 cell cycle arrest via Cyclin D and cyclin-dependent kinase 4 pathways in OVCAR-3 and Caov-4 cell lines
Author(s) -
Hamidreza Joshaghani,
Seyyed Mehdi Jafari,
Mahmoud Aghaei,
Mojtaba Panjehpour,
Hamideh Abedi
Publication year - 2017
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.199381
Subject(s) - cell cycle , cyclin a , cyclin d , cyclin d1 , microbiology and biotechnology , cyclin b , cancer research , cell cycle checkpoint , cyclin e , biology , cell growth , chemistry , cell , biochemistry
The cell cycle, a vital process that involves in cells' growth and division, lies at the heart of cancer. It has been shown that IB-MECA, an A3 adenosine receptor agonist inhibits the proliferation of cancer cells by inducing cell cycle arrest in several tumors. In this study, we evaluated the role of IB-MECA inhibition in cell cycle progression in ovarian cancer cells.