Open AccessCytogenetic damage from hyperthermia,6 MV X-rays, and topotecan in glioblastoma spheroids, simultaneously, and separately
Author(s) -
Ali Neshasteh-Riz,
Nazila Eyvazzadeh,
Alireza Rostami,
Elmira Azzizolahi
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.189239
Subject(s) - topotecan , spheroid , radiation therapy , hyperthermia , clonogenic assay , glioma , cancer research , irradiation , nuclear medicine , glioblastoma , medicine , chemotherapy , chemistry , cell , biology , cell culture , physics , nuclear physics , genetics , biochemistry
Glioblastoma multiform (GBM) is one of the most common brain tumors. Surgery, radiation therapy, hyperthermia, and chemotherapy are the most common treatments for brain tumors such as GBM. This study investigated the cytogenetic damage caused by hyperthermia, radiation (6 MV-X-rays), and topotecan in glioma spheroids, simultaneously and separately.