Open AccessMalignancy associated hemophagocytic lymphohistiocytosis in children
Author(s) -
Amitabh Singh,
Indar Kumar Sharawat,
Rachna Seth
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.188437
Subject(s) - hemophagocytic lymphohistiocytosis , medicine , malignancy , pediatrics , disease , lymphoma , chemotherapy , hemophagocytosis , immunology , bone marrow , pancytopenia
Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of immune dysregulation resulting in abnormal T-cell activation and inflammatory cytokine production which produces a constellation of clinical features unique to HLH. Pediatric secondary HLH is usually triggered by infection, malignancy, or rheumatological disorders. The diagnosis of malignancy-associated HLH (MA-HLH) poses a difficult challenge as clinical features may be attributed to the underlying disease or chemotherapy. Our study aimed to see the occurrence of this rare entity at our centre.