Open AccessSynergistic effect of temozolomide and thymoquinone on human glioblastoma multiforme cell line (U87MG)
Author(s) -
Mona Pazhouhi,
Reyhaneh Sariri,
Mohammad Rasoul Khazaei,
MohammadTaher Moradi
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.187241
Subject(s) - temozolomide , thymoquinone , cancer research , chemistry , lactate dehydrogenase , viability assay , cell culture , matrix metalloproteinase , cytotoxicity , pharmacology , cell , medicine , glioblastoma , biology , in vitro , enzyme , biochemistry , genetics , antioxidant
Temozolomide (TMZ) is an alkylating agent used for glioblastoma multiforme (GBM) treatment. Nevertheless, resistance to TMZ is a major obstacle to successful treatment of this cancer. The aim of the present study was to investigate the effects of TMZ and thymoquinone (TQ) on U87MG cell line.