Open AccessImmunohistochemical study of the expression of human chorionic gonadotropin-β in salivary gland tumors
Author(s) -
Meda Samatha,
Bernard Ajay Reginald,
Basireddy Siva Reddy
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.184523
Subject(s) - immunohistochemistry , immunostaining , human chorionic gonadotropin , pleomorphic adenoma , salivary gland , pathology , mucoepidermoid carcinoma , adenoid cystic carcinoma , adenoma , biology , carcinoma , medicine , hormone , endocrinology
Human chorionic gonadotropin-β (hCGβ) is a hormone glycoprotein usually secreted by trophoblastic cells in early pregnancy and helps in growth and development of the embryo. While many trophoblastic and nontrophoblastic malignancies express elevated levels of hCGβ in serum, increased immunohistochemical reactivity has also been reported in malignant and aggressive tumors, thus serving as a marker. As limited studies exist on tumors of the oral- and para-oral region, it prompted us to observe the immunohistochemical expression of hCGβ in salivary gland tumors.