Clinical significance of interleukin-6 in diagnosis of lung, oral, esophageal, and gall bladder carcinomas | Zendy

Anjali Vinocha | Zendy; Rajesh K. Grover | Zendy; Rani Deepak | Zendy

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Clinical significance of interleukin-6 in diagnosis of lung, oral, esophageal, and gall bladder carcinomas

Author(s) -

Anjali Vinocha,

Rajesh K. Grover,

Rani Deepak

Publication year - 2018

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.183217

Subject(s) - medicine , esophageal cancer , lung cancer , gastroenterology , bladder cancer , cancer , carcinogenesis , cytokine , gallbladder , carcinoma , lung , oncology

Chronic inflammation predisposes to cancer. Cytokines play an essential role in cancer pathogenesis. Interleukin-6 (IL-6) is a pleiotropic cytokine that enables growth and differentiation of tumors. The effects of IL-6 are mediated by signal transducers and activators of transcription 3 (STAT3). STAT3 deficiency reduced tumor incidence and growth while STAT3 hyperactivation has an opposite effect; also it negatively regulates p53 gene. IL-6/STAT3 signaling is crucial in carcinogenesis linked to inflammation. Increased IL-6 levels are observed in cancer. Studies investigating the role of IL-6 is limited.

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