Open AccessClinical significance of interleukin-6 in diagnosis of lung, oral, esophageal, and gall bladder carcinomas
Author(s) -
Anjali Vinocha,
Rajesh K. Grover,
Rani Deepak
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.183217
Subject(s) - medicine , esophageal cancer , lung cancer , gastroenterology , bladder cancer , cancer , carcinogenesis , cytokine , gallbladder , carcinoma , lung , oncology
Chronic inflammation predisposes to cancer. Cytokines play an essential role in cancer pathogenesis. Interleukin-6 (IL-6) is a pleiotropic cytokine that enables growth and differentiation of tumors. The effects of IL-6 are mediated by signal transducers and activators of transcription 3 (STAT3). STAT3 deficiency reduced tumor incidence and growth while STAT3 hyperactivation has an opposite effect; also it negatively regulates p53 gene. IL-6/STAT3 signaling is crucial in carcinogenesis linked to inflammation. Increased IL-6 levels are observed in cancer. Studies investigating the role of IL-6 is limited.