Open AccessCigarette smoke condensate could promote human bronchial epithelial BEAS-2B cell migration through shifting neprilysin trafficking
Author(s) -
Kun Yang,
Chuanfeng Zhang,
Lei Sun,
Dong Liu,
Xin Hong
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.183182
Subject(s) - neprilysin , chemistry , microbiology and biotechnology , internalization , cell , cell growth , cell migration , lysosome , cancer research , biology , biochemistry , enzyme
Recent studies have suggested neprilysin (NEP) play a key role in cigarette smoke-induced nonsmall-cell lung carcinoma; however, the detailed mechanism was still unclear. Here, we employed in vitro human bronchial epithelial BEAS-2B cells to investigate whether and how NEP involved in cigarette smoke condensate (CSC)-induced cancer occurrence.