Open AccessInvestigation of melanoma-associated antigen A4 cancer/testis antigen clinical relevance in esophageal squamous cell carcinoma
Author(s) -
Soodabeh Abbasi Sani,
Mohammad Mahdi Forghanifard,
N Sharifi,
Mahnaz Hashemi Bidokhti,
Alireza Jian Bagherpoor,
Mohammad Reza Abbaszadegan
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.183180
Subject(s) - immunohistochemistry , antigen , cancer , malignancy , clinical significance , medicine , melanoma , cancer research , esophageal cancer , oncology , pathology , biology , immunology
Esophageal squamous cell carcinoma (ESCC) is considered as the seventh most common cancer worldwide, and the second prevalent malignancy in the north of Iran. A subfamily group of tumor-specific antigens, commonly specified as cancer/testis antigens (CTAs), are expressed restrictedly in testis, ovary, and placenta. Melanoma-associated antigen A4 (MAGEA4) as a CTA is overexpressed in a variety of cancers. Expressional analysis of MAGEA4 protein in ESCC may be useful to investigate its clinical relevance leading to effective improvements in ESCC diagnosis and treatment.