Open AccessRenin-producing germ cell tumor in the pineal apparatus and mediastinum: A rare case report
Author(s) -
Manabu Uematsu,
Hiroshi Yokouchi,
Yoshinori Tanino,
Mitsuru Munakata
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.180682
Subject(s) - mediastinum , renin–angiotensin system , medicine , pathological , germ cell tumors , plasma renin activity , mediastinal tumor , pathology , radiology , chemotherapy , blood pressure
Ectopic extrarenal renin-producing tumor is a rare disease with approximately 30 case reports in English literature. We herein present the first case of renin-producing germ cell tumors in the pineal apparatus and mediastinum. A 26-year-old man who had undergone craniotomy for the treatment of pineal tumor was found to have hypertension at a regular visit postoperatively. Laboratory findings revealed high plasma levels of renin activity and that of aldosterone concentration. Chest computed tomography demonstrated a large tumor in the mediastinum. The pathological findings revealed the mediastinal germ cell tumor positive for renin. The present case suggests that for young patients presenting with hypertension with a mediastinal tumor, the possibility of a renin-producing tumor should be considered.