Open AccessExpression of Numb and Gli1 in malignant pleural mesothelioma and their clinical significance
Author(s) -
Caiqing Zhang,
Yanmeng Kang,
Ruiping Ma,
Feng Chen,
Fangfang Chen,
Xueli Dong
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.180614
Subject(s) - numb , gli1 , immunohistochemistry , medicine , pathology , cancer research , hedgehog signaling pathway , oncology , biology , signal transduction , biochemistry , genetics
Malignant pleural mesothelioma (MPM) is a highly lethal and refractory to multimodal treatment tumor. Numb is considered as a tumor suppressor playing critical roles in determining cell fate and has been shown to target the oncogenic transcription factor Gli1 for Itch-dependent ubiquitination, resulting in suppression of the oncogenic sonic hedgehog signaling in medulloblastoma. This study was designed to analysis the role of Numb and Gli1 in MPM.