Open AccessModulation of the gamma-secretase activity as a therapy against human hepatocellular carcinoma
Author(s) -
Yuqing Shen,
Ying Yin,
Yaqin Peng,
Dan Lv,
Fengqin Miao,
Fei Dou,
Jianqiong Zhang
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.174542
Subject(s) - presenilin , hepatocellular carcinoma , gamma secretase , transfection , cancer research , western blot , cell culture , amyloid precursor protein secretase , chemistry , biology , medicine , amyloid precursor protein , microbiology and biotechnology , biochemistry , gene , alzheimer's disease , genetics , disease
Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide. The discovery of new therapies against HCC is highly dependable on finding molecules which play essential roles in cancer development. The objective of this study was to evaluate the activity of gamma secretase (γ-secretase), and the antitumor effects of a γ-secretase inhibitor (GSI) in HCC.