Open AccessFactors regulating nuclear factor-kappa B activation in esophageal cancer cells: Role of bile acids and acid
Author(s) -
Mohamed Abdel-Latif,
H. Inoue,
Dermot Kelleher,
John V. Reynolds
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.174525
Subject(s) - bile acid , transcription factor , deoxycholic acid , transfection , cancer research , biology , chemistry , microbiology and biotechnology , biochemistry , gene
Gastroesophageal reflux disease is considered to be a major risk in the development of esophageal adenocarcinoma. Nuclear factor-kappa B (NF-κB) plays important roles in the regulation of several genes coding for cytokines, cell proliferation, and apoptosis. To understand the role of bile and acid in the causation of esophageal cancer, we have examined the effects of bile acids and acid on NF-κB activation in the esophageal epithelial cells OE33 and SKGT-4 qualitatively and quantitatively.