Open AccessSignificance of expression of suppressor of cytokine signaling proteins: Suppressor of cytokine signaling-1, suppressor of cytokine signaling-2, and suppressor of cytokine signaling-3 in papillary thyroid cancer
Author(s) -
Toral P Kobawala,
Trupti Trivedi,
Kinjal Gajjar,
Girish H. Patel,
Nandita Ghosh
Publication year - 2017
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.174172
Subject(s) - papillary thyroid cancer , socs3 , thyroid cancer , cytokine , suppressor of cytokine signaling 1 , cancer research , socs2 , signal transduction , suppressor of cytokine signalling , medicine , oncogene , cancer , janus kinase , suppressor , biology , microbiology and biotechnology , cell cycle
Uncontrolled cytokine signal transduction largely associated with oncogene activation, can have disastrous biological consequences. The suppressor of cytokine signaling (SOCS) proteins represent one of the mechanisms by which this rampant signaling can be dissipated. Thus, we aimed to study the expression of SOCS-1, SOCS-2, and SOCS-3 in patients having benign thyroid disease and papillary thyroid cancer.