Open AccessPromoter methylation of human mutL homolog 1 and colorectal cancer risk
Author(s) -
Bian Shi,
Jiayou Chu,
Qilong Gao,
Tong-de Tian
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.172587
Subject(s) - meta analysis , methylation , odds ratio , publication bias , confidence interval , medicine , colorectal cancer , subgroup analysis , dna methylation , oncology , relative risk , gastroenterology , cancer , biology , genetics , gene , gene expression
Several studies suggested that promoter methylation of human mutL homolog 1 (hMLH1) was associated with the risk of colorectal cancer (CRC). However, other studies did not indicate the same results. To derive a more comprehensive estimation of the association between hMLH1 methylation and CRC risk, we conducted a meta-analysis.