Open AccessCyclooxygenase-2 gene polymorphisms and susceptibility to hepatocellular carcinoma
Author(s) -
Wei Xu,
YaPing Huang,
Ting Zhang,
Lingyun Zhao,
Jun Fan,
Lanjuan Li
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.172110
Subject(s) - hepatocellular carcinoma , odds ratio , medicine , cochrane library , confidence interval , meta analysis , gastroenterology , subgroup analysis , allele , cyclooxygenase , oncology , web of science , gene , biology , genetics , enzyme , biochemistry
The association between cyclooxygenase-2 (COX-2) gene polymorphisms and hepatocellular carcinoma (HCC) has been widely reported, but the results are still controversial. To clarify the effect of COX-2 -1195G/A (rs689466), -765G/C (rs20417), and +8473T/C (rs5275) polymorphisms on HCC risk, a meta-analysis was performed.