Open AccessUpregulation of miR-371-373 cluster, a human embryonic stem cell specific microRNA cluster, in esophageal squamous cell carcinoma
Author(s) -
Majid Ghasemi,
Nader Mansour Samaei,
Seyed Javad Mowla,
Mohammad Shafiee,
Mohammad Vasei,
Nadia Ghasemian
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.171361
Subject(s) - microrna , carcinogenesis , downregulation and upregulation , embryonic stem cell , biology , cancer research , cancer , stem cell , gene , cancer stem cell , cell , pathology , genetics , medicine
Esophageal squamous cell carcinoma (ESCC) is the most common subtype of esophageal cancer in Iran. MicroRNAs (miRNAs) are a class of noncoding RNAs that are found to be involved in different processes and can play a role in tumorigenesis and result in cancer. MiR-371, miR-372, and miR-373 are a gene cluster that is located in the region of the human chromosome of 19q13.4. They are specifically expressed in human embryonic stem cells (ESCs) and involved in the maintenance of the stemness features through regulating the expression of certain key genes and signaling pathways. The present study investigated the potential expression of miR-371-373 cluster in tumor and nontumor tissues of ESCC.