Open AccessTumour suppressive effects of WEE1 gene silencing in neuroblastomas
Author(s) -
Ahmad Hosseini,
Mansooreh Jaberipour,
Mahboobeh Razmkhah,
Rahnama Susan,
Mojtaba Habibagahi
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.165861
Subject(s) - wee1 , cancer research , small hairpin rna , biology , gene silencing , cell cycle , cell growth , rna interference , small interfering rna , cell culture , cell , microbiology and biotechnology , transfection , gene , genetics , cyclin dependent kinase 1 , gene knockdown , rna
WEE1, a member of serine/threonine protein kinase family is the master inhibitor of cyclin-dependent kinase 1 in cell cycle. Over-expression of WEE1 in glioblastomas (GBMs) and some other cancers has been shown. Here, we investigated the expression of WEE1 in 13 brain samples from GBM patients and two GBM cell lines. Further to that, we asked whether if knocking down WEE1 expression in the cell lines change tumor cells' reaction.