Open AccessGene mutation characteristics of nonsmall-cell lung carcinoma patients with wild-type epidermal growth factor receptor and sensitivity to Tarceva therapy
Author(s) -
Yan Cui,
Jiahua Xu,
Xuefang Liang,
Ye Tian,
Zhenlin Zhan,
Daliang Qi
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.163847
Subject(s) - kras , epidermal growth factor receptor , neuroblastoma ras viral oncogene homolog , cancer research , hras , pten , medicine , targeted therapy , lung cancer , mutation , wild type , oncology , gene , cancer , biology , colorectal cancer , pi3k/akt/mtor pathway , signal transduction , mutant , genetics
To explore characteristic gene mutations in nonsmall-cell lung carcinoma (NSCLC) patients with wild-type epidermal growth factor receptor (EGFR) and sensitivity to Tarceva therapy; to observe the efficacy and safety of Tarceva therapy for NSCLC patients with wild-type EGFR.