Open AccessThe effects of gene therapy with granulocyte-macrophage colony-stimulating factor in the regression of tumor masses in fibrosarcoma mouse model
Author(s) -
Saiedeh RaziSoofiyani,
Tohid Kazemi,
Farzaneh Lotfipour,
Leila Mohammadnejad,
Somayeh HallajNezhadi,
Siamak Sandoghchian Shotorbani,
Akbar Mohammad Hosseini,
Behzad Baradaran
Publication year - 2017
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.159083
Subject(s) - fibrosarcoma , cytokine , granulocyte macrophage colony stimulating factor , immunohistochemistry , cancer research , ht1080 , genetic enhancement , transfection , microbiology and biotechnology , monocyte , biology , medicine , pathology , immunology , cell culture , gene , biochemistry , genetics
Cytokine gene therapy is one of the cancer treatment strategies. Recently, granulocyte-monocyte colony-stimulating factor (GM-CSF), as an important cytokine in activating dendritic cells and boosting the anti-tumor immune responses, has been utilized as an immunotherapeutic agent in cancer gene therapy. The purpose of the present investigation was to study the GM-CSF gene therapy effects in regression of tumor masses in fibrosarcoma mouse model.