Open AccessTP 53 polymorphisms and melanoma: A meta-analysis
Author(s) -
Ting He,
Jinhu Wu,
Yong Chen,
Junzhi Zhang
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.157329
Subject(s) - genotype , meta analysis , odds ratio , melanoma , allele , heterozygote advantage , confidence interval , genetic model , medicine , biology , genetics , allele frequency , oncology , gene
p53 is a tumor suppressor encoded by the TP53 gene. It is critical in activating deoxyribonucleic acid (DNA) repair upon damage, and thus preserving genomic stability. TP53 is implicated in tumor progression. Melanoma results from transformed melanocytes in the skin. Data gathered on the association between the TP53 Arg72, Pro72 (rs1042522; G>C) polymorphism and melanoma are conflicting.