Open AccessTreatment of undifferentiated colorectal cancer cells with fish-oil derived docosahexaenoic acid triggers caspase-3 activation and apoptosis
Author(s) -
Parinaz Ahangar,
Mohammad Reza Sam,
Vahid Nejati,
Reza Habibian
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.157326
Subject(s) - survivin , docosahexaenoic acid , apoptosis , colorectal cancer , cancer research , caspase 8 , cancer cell , cancer , caspase 3 , caspase , chemistry , biology , medicine , programmed cell death , biochemistry , polyunsaturated fatty acid , fatty acid
The effectiveness of chemotherapy is often limited by the side effects on normal tissues. Consequently, the search for new therapeutic agents with minimal toxicity is of particular interest in cancer management. Many studies have shown that docosahexaenoic acid (DHA) have cytotoxic effects against different kinds of cancer cells. However, little attention has been paid to explore the effect of DHA on undifferentiated colorectal cancer cells. In this study, the effects of DHA on LS174T cells as an early stage of tumor initiation were investigated.